CROSSLINKED HYALURONAN DERIVATIVE, METHOD OF PREPARATION THEREOF, HYDROGEL AND MICROFIBERS BASED THEREON

The invention relates to a crosslinked hyaluronan derivative in the form of a hydrogel or microfibers, and to a method of preparation thereof, consisting in a C-C coupling reaction. The C-C coupling reaction is performed via reaction of a hyaluronan derivative carrying a terminal aryl-halide and/or...

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Bibliographische Detailangaben
Hauptverfasser:	JOUKLOVA ZUZANA, VELEBNY VLADIMIR, HUERTA ANGELES GLORIA, PRIKOPOVA EVA
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBONFILAMENTS CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS,THREADS, FIBRES, BRISTLES OR RIBBONS CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF METALLURGY NATURAL OR ARTIFICIAL THREADS OR FIBRES ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES SPINNING TEXTILES THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	The invention relates to a crosslinked hyaluronan derivative in the form of a hydrogel or microfibers, and to a method of preparation thereof, consisting in a C-C coupling reaction. The C-C coupling reaction is performed via reaction of a hyaluronan derivative carrying a terminal aryl-halide and/or aryl-borate group, and a hyaluronan derivative carrying an alkenyl or alkynyl group, in water, phosphates buffer or a mixture of an organic acid and an alcohol, and in the presence of a palladium active catalyst. The palladium active catalyst may be e.g. a complex of palladium (II) acetate and an inorganic or organic base, or a complex of palladium (II) and 2-amino-4,6-dihydroxypyrimidine.