NEW INTERMEDIATES OF GEFITINIB AND A PREPARATION METHOD THEREOF

Provided in the present invention are an intermediate compound useful in preparing Gefitinib and a method for preparing the same. The intermediate compound is used to prepare high purity high yield Gefitinib. The method for preparing compound of chemical formula 7 comprises the steps of: a) preparin...

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Bibliographische Detailangaben
Hauptverfasser:	SON, HOE JOO, KIM, YOUNG TAEG, PARK, YONG KYU, JO, BOUNG SUN, KIM, JUNG HEE, OH, DO YEON
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided in the present invention are an intermediate compound useful in preparing Gefitinib and a method for preparing the same. The intermediate compound is used to prepare high purity high yield Gefitinib. The method for preparing compound of chemical formula 7 comprises the steps of: a) preparing a compound of chemical formula 6 by reducing a compound of following chemical formula 5; and b) cyclizying the compound of chemical fomula 6 and unsatureated six-atom heterocycle compound with an organic base in presence of alcohol solvent having one to four carbon atoms to preparing a compound of chemical formula 7.