REAL-TIME ASSAY FOR THE DETECTION OF BOTULINUM TOXIN

The present invention portably rapidly tests and detects the existence of a biological active toxin such as a botulinum toxin. Proteolysis activity of BoNT/A is measured by detection of peptide cleavage. A fluorescence temperament induces fluorescence which is opened and increased by the BoNT/A. The...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	STITES FRANCES LOUISE, PLOCHOCK DEBORAH L, MILLS JEFFREY HAROLD, SULIMAN HUDA SIRAGELDIN, CHAMBERLIN LISA HELEN, MOSHIER TIMOTHY FRANCIS, MASSULIK STACEY ANN, BARRETT OLIVIA JENNIFER, DOCTOR KENTON ARTHUR
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The present invention portably rapidly tests and detects the existence of a biological active toxin such as a botulinum toxin. Proteolysis activity of BoNT/A is measured by detection of peptide cleavage. A fluorescence temperament induces fluorescence which is opened and increased by the BoNT/A. The fluorescence is monitored in real time using a fluorescence detection tool, a real time PCR system, which is deformed to execute a specific detection algorithm for detecting a target toxin.