VARIANT ACTIVIN RECEPTOR POLYPEPTIDES AND USES THEREOF

VARIANT ACTIVIN RECEPTOR POLYPEPTIDES AND USES THEREOF

The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KWAK KEITH SOO NYUNG, SUN, JEONG HOON, HAN HQ, ZHOU XIAOLAN, TAM LEI TING TONY
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.