THE WATER-INSOLUBLE ZOLEDRONATE COVERED WITH AMORPHOUS SURFACTANT
The present invention provides zoledronate covered with an amorphous surfactant, which is a poorly water-soluble substance and includes 100 parts by weight of zoledronate and the surfactant having two or more alkyl chains bonded to hydrophilic parts. The amount of the surfactant is 10-200 parts by w...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; kor |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | KWEON, DON SUN YOU, WOO YOUNG |
| description | The present invention provides zoledronate covered with an amorphous surfactant, which is a poorly water-soluble substance and includes 100 parts by weight of zoledronate and the surfactant having two or more alkyl chains bonded to hydrophilic parts. The amount of the surfactant is 10-200 parts by weight based on the zoledronate. The surfactant is bonded as amorphously surrounding the outside of the zoledronate and is dissolved in water in an emulsion type. The zoledronate to which the surfactant is bonded has 0.5 to 30 micrometers of average diameter, and ±200% average range of size based on the diameter. The water-insoluble zoledronate covered with amorphous surfactant of the present invention can increase contents of dissolvable zoledronate up to tens to hundreds times more than a conventional method of solubilizing the zoledronate in a liposome form or an emulsion form. [Reference numerals] (AA) Hydrophilic part of a surfactant; (BB) Slightly soluble material; (CC) Surfactant; (DD) Alkyl part of the surfactant |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_KR20140043581A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>KR20140043581A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_KR20140043581A3</originalsourceid><addsrcrecordid>eNrjZHAM8XBVCHcMcQ3S9fQL9vcJdfJxVYjy93F1CfL3AworOPuHuQa5uiiEe4Z4KDj6-gcFePiHBisEhwa5OTqHOPqF8DCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSSeO8gIwNDEwMDE2NTC0NHY-JUAQC48Cw-</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>THE WATER-INSOLUBLE ZOLEDRONATE COVERED WITH AMORPHOUS SURFACTANT</title><source>esp@cenet</source><creator>KWEON, DON SUN ; YOU, WOO YOUNG</creator><creatorcontrib>KWEON, DON SUN ; YOU, WOO YOUNG</creatorcontrib><description>The present invention provides zoledronate covered with an amorphous surfactant, which is a poorly water-soluble substance and includes 100 parts by weight of zoledronate and the surfactant having two or more alkyl chains bonded to hydrophilic parts. The amount of the surfactant is 10-200 parts by weight based on the zoledronate. The surfactant is bonded as amorphously surrounding the outside of the zoledronate and is dissolved in water in an emulsion type. The zoledronate to which the surfactant is bonded has 0.5 to 30 micrometers of average diameter, and ±200% average range of size based on the diameter. The water-insoluble zoledronate covered with amorphous surfactant of the present invention can increase contents of dissolvable zoledronate up to tens to hundreds times more than a conventional method of solubilizing the zoledronate in a liposome form or an emulsion form. [Reference numerals] (AA) Hydrophilic part of a surfactant; (BB) Slightly soluble material; (CC) Surfactant; (DD) Alkyl part of the surfactant</description><language>eng ; kor</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140410&DB=EPODOC&CC=KR&NR=20140043581A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76302</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140410&DB=EPODOC&CC=KR&NR=20140043581A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KWEON, DON SUN</creatorcontrib><creatorcontrib>YOU, WOO YOUNG</creatorcontrib><title>THE WATER-INSOLUBLE ZOLEDRONATE COVERED WITH AMORPHOUS SURFACTANT</title><description>The present invention provides zoledronate covered with an amorphous surfactant, which is a poorly water-soluble substance and includes 100 parts by weight of zoledronate and the surfactant having two or more alkyl chains bonded to hydrophilic parts. The amount of the surfactant is 10-200 parts by weight based on the zoledronate. The surfactant is bonded as amorphously surrounding the outside of the zoledronate and is dissolved in water in an emulsion type. The zoledronate to which the surfactant is bonded has 0.5 to 30 micrometers of average diameter, and ±200% average range of size based on the diameter. The water-insoluble zoledronate covered with amorphous surfactant of the present invention can increase contents of dissolvable zoledronate up to tens to hundreds times more than a conventional method of solubilizing the zoledronate in a liposome form or an emulsion form. [Reference numerals] (AA) Hydrophilic part of a surfactant; (BB) Slightly soluble material; (CC) Surfactant; (DD) Alkyl part of the surfactant</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAM8XBVCHcMcQ3S9fQL9vcJdfJxVYjy93F1CfL3AworOPuHuQa5uiiEe4Z4KDj6-gcFePiHBisEhwa5OTqHOPqF8DCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSSeO8gIwNDEwMDE2NTC0NHY-JUAQC48Cw-</recordid><startdate>20140410</startdate><enddate>20140410</enddate><creator>KWEON, DON SUN</creator><creator>YOU, WOO YOUNG</creator><scope>EVB</scope></search><sort><creationdate>20140410</creationdate><title>THE WATER-INSOLUBLE ZOLEDRONATE COVERED WITH AMORPHOUS SURFACTANT</title><author>KWEON, DON SUN ; YOU, WOO YOUNG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20140043581A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2014</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KWEON, DON SUN</creatorcontrib><creatorcontrib>YOU, WOO YOUNG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KWEON, DON SUN</au><au>YOU, WOO YOUNG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>THE WATER-INSOLUBLE ZOLEDRONATE COVERED WITH AMORPHOUS SURFACTANT</title><date>2014-04-10</date><risdate>2014</risdate><abstract>The present invention provides zoledronate covered with an amorphous surfactant, which is a poorly water-soluble substance and includes 100 parts by weight of zoledronate and the surfactant having two or more alkyl chains bonded to hydrophilic parts. The amount of the surfactant is 10-200 parts by weight based on the zoledronate. The surfactant is bonded as amorphously surrounding the outside of the zoledronate and is dissolved in water in an emulsion type. The zoledronate to which the surfactant is bonded has 0.5 to 30 micrometers of average diameter, and ±200% average range of size based on the diameter. The water-insoluble zoledronate covered with amorphous surfactant of the present invention can increase contents of dissolvable zoledronate up to tens to hundreds times more than a conventional method of solubilizing the zoledronate in a liposome form or an emulsion form. [Reference numerals] (AA) Hydrophilic part of a surfactant; (BB) Slightly soluble material; (CC) Surfactant; (DD) Alkyl part of the surfactant</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; kor |
| recordid | cdi_epo_espacenet_KR20140043581A |
| source | esp@cenet |
| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | THE WATER-INSOLUBLE ZOLEDRONATE COVERED WITH AMORPHOUS SURFACTANT |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T17%3A42%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=KWEON,%20DON%20SUN&rft.date=2014-04-10&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EKR20140043581A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |