PYRROLOPYRIMIDINE COMPOUNDS AS CDK INHIBITORS

The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need...

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Bibliographische Detailangaben
Hauptverfasser:	LI YUE, SUNG, MOO, DAGOSTIN CLAUDIO, BROOKS CLINTON A, MORTENSON PAUL, SMITH TROY, BESONG GILBERT, HE GUO, HOWARD STEVEN, WRONA WOJCIECH, LAGU BHARAT, BRAIN CHRISTOPHER THOMAS, CONGREVE MILES STUART, HOU YING, LU YIPIN, WOODHEAD STEVEN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.