COMPOSITION CONTAINING ASCORBIC ACID FOR ORAL ADMINISTRATION WITH CONTROLLED RELEASE PROPERTY AND METHOD OF ANALYZING THE SAME

PURPOSE: A tablet composition for oral administration containing controlled release ascorbic acid and an analysis method thereof are provided to continuously maintain ascorbic acid concentration in blood. CONSTITUTION: A tablet composition for oral administration contains 40-70 wt% of ascorbic acid, 10-30 wt% of high viscosity hydroxypropyl methyl cellulose as a release controlling agent polymer, 10-30 wt% of excipient, 3-7 wt% of a binder, and 0.5-2 wt% of a lubricant. The viscosity of hydroxypropyl methyl cellulose is 4,000-200,000 cps. The binder is hydroxypropyl methyl cellulose with a viscosity of 4-10 cps. The excipient is selected from lactose, mannitol, and microcrystalline cellulose. [Reference numerals] (AA) Elution rate(%); (BB) Example 2-5; (CC) Example 2-3; (DD) Example 2-6; (EE) Example 2-7; (FF) Time(hr)