PROCESSES FOR THE PREPARATION OF 5-LIPOOXYGENASE ACTIVATING PROTEIN INHIBITORS AND THEIR INTERMEDIATES

PROCESSES FOR THE PREPARATION OF 5-LIPOOXYGENASE ACTIVATING PROTEIN INHIBITORS AND THEIR INTERMEDIATES

The present invention provides processes useful for preparing 5-lipoxygenase activating protein (FLAP) inhibitors and their intermediates. In particular, processes for preparing 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethy...

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Hauptverfasser: STOCK NICHOLAS SIMON, KENNEDY ANDREW, HERMITAGE STEPHEN ANDREW, MASON ANDREW MCMURTRIE, SCOTT MARK SIMON, KEEL TREVOR RAYMOND, SMITH NEIL MICHAEL, HUTCHINSON JOHN HOWARD, GRAHAM JONATHAN PAUL, WALLIS CHRISTOPHER JOHN, TURNER PETER GRAHAM, WILLACY ROBERT DAVID, HARLING SANDRA JANE, TATENO YUICHI, GARCIA SANDRINE, TROUW LEONTINE SASKIA, CRAWFORD CLAIRE FRANCES, HENLEY NICHOLAS PAUL
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention provides processes useful for preparing 5-lipoxygenase activating protein (FLAP) inhibitors and their intermediates. In particular, processes for preparing 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, the anhydrous Form C polymorph of sodium 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionate, and intermediates useful in said processes are provided.