MRI CONTRAST AGENT COATED WITH CARBOXYLATED MANNAN AND METHOD FOR PRODUCING THE SAME

MRI CONTRAST AGENT COATED WITH CARBOXYLATED MANNAN AND METHOD FOR PRODUCING THE SAME

PURPOSE: An MRI contrast coated with carboxyl group-introduced mannan is provided to ensure high in vivo stability and biocompatibility and to visualize antigen presenting cells and tissues including antigen presenting cells. CONSTITUTION: A superparamagnetic nanoparticle MRI contrast coated with ca...

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Hauptverfasser: KWON, AN SUNG, KANG, SANG HYEON, JEONG, YONG YEON, JUN, SOO YOUN, KIM, YOU KYOUNG, YOON, SEONG JUN, PARK, IN KYU, NAM, GUNG RAN, CHO, CHONG SU, KIM, WON JONG
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Sprache:eng ; kor
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator KWON, AN SUNG
KANG, SANG HYEON
JEONG, YONG YEON
JUN, SOO YOUN
KIM, YOU KYOUNG
YOON, SEONG JUN
PARK, IN KYU
NAM, GUNG RAN
CHO, CHONG SU
KIM, WON JONG
description PURPOSE: An MRI contrast coated with carboxyl group-introduced mannan is provided to ensure high in vivo stability and biocompatibility and to visualize antigen presenting cells and tissues including antigen presenting cells. CONSTITUTION: A superparamagnetic nanoparticle MRI contrast coated with carboxylic acid-mannan visualizes antigen-presenting cells and tissues containing the cells. The cells include dendritic cells, macrophage, and B-cells. The carboxylic acid-mannan is prepared from aldehyde-mannan. A method for preparing the MRI contrast comprises: a step of synthesizing superparamagnetic nanoparticles; a step of introducing aldehyde groups to mannan to prepare aldehyde-mannan; a step of oxidizing the alhehyde-mannan to prepare carboxyl-mannan; and a step of coating the superparamagnetic nanoparticles with the carboxylic acid-mannan.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title MRI CONTRAST AGENT COATED WITH CARBOXYLATED MANNAN AND METHOD FOR PRODUCING THE SAME
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