MRI CONTRAST AGENT COATED WITH CARBOXYLATED MANNAN AND METHOD FOR PRODUCING THE SAME

PURPOSE: An MRI contrast coated with carboxyl group-introduced mannan is provided to ensure high in vivo stability and biocompatibility and to visualize antigen presenting cells and tissues including antigen presenting cells. CONSTITUTION: A superparamagnetic nanoparticle MRI contrast coated with ca...

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Hauptverfasser:	KWON, AN SUNG, KANG, SANG HYEON, JEONG, YONG YEON, JUN, SOO YOUN, KIM, YOU KYOUNG, YOON, SEONG JUN, PARK, IN KYU, NAM, GUNG RAN, CHO, CHONG SU, KIM, WON JONG
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PURPOSE: An MRI contrast coated with carboxyl group-introduced mannan is provided to ensure high in vivo stability and biocompatibility and to visualize antigen presenting cells and tissues including antigen presenting cells. CONSTITUTION: A superparamagnetic nanoparticle MRI contrast coated with carboxylic acid-mannan visualizes antigen-presenting cells and tissues containing the cells. The cells include dendritic cells, macrophage, and B-cells. The carboxylic acid-mannan is prepared from aldehyde-mannan. A method for preparing the MRI contrast comprises: a step of synthesizing superparamagnetic nanoparticles; a step of introducing aldehyde groups to mannan to prepare aldehyde-mannan; a step of oxidizing the alhehyde-mannan to prepare carboxyl-mannan; and a step of coating the superparamagnetic nanoparticles with the carboxylic acid-mannan.