COMPOSITION FOR PREVENTING IMMUNE-RESPOSE COMPRISING PLACENTA DERIVED STEM CELL

PURPOSE: A composition for immunological reaction suppression including placenta originated stem cells is provided to be used for an acute or chronic Graft Versus Host Disease therapeutic agent. CONSTITUTION: A composition for immunological reaction suppression includes placenta originated stem cell as an active ingredient. The mesenchyme stem cell is originated from chorionic plate film of placenta. The mesenchyme stem cell expresses CD105, CD44, CD73 or CD90 cell surface antigens which are lobus medius indicators. The composition induces reduction of S phase and G2/M(mitotic) phase and increase of cell cycle G0/G1 phase of lymphocyte cell. The composition reduces CD69+ cell. The composition suppresses immune reaction for the transplanted organs or cells. The transplanted organs or cells are isotransplant or xenograft. The composition is used for treatment or prevention of autoimmune diseases or rejection of internal organ transplant reaction. The autoimmune disease is GVHD(graft-versus-host disease). The composition is manufactured in the injection form.