PREPARATION METHOD OF (S)-BEPOTASTINE
PURPOSE: A method for preparing (S)-bepotastine is provided to enhance yield and optical purity of (S)-bepotastine. CONSTITUTION: A method for preparing (S)-bepotastine comprises: a step of performing optical resolution of a compound of chemical formula 2 under the presence of an organic solvent to...
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| creator | OH, SAE HAN KIM, SHIN JONG HAN, SONG YI JEUNG, CHUN OH KIM, MIN SUNG |
| description | PURPOSE: A method for preparing (S)-bepotastine is provided to enhance yield and optical purity of (S)-bepotastine. CONSTITUTION: A method for preparing (S)-bepotastine comprises: a step of performing optical resolution of a compound of chemical formula 2 under the presence of an organic solvent to prepare a compound of chemical formula 3; and a step of reacting the compound of chemical formula 3 under an acidic condition to prepare a compound of chemical formula 1. The organic solvent includes ethyl acetate, methylene chloride, acetone, hexane, diethyl ether, or diisoporpyl ether. |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PREPARATION METHOD OF (S)-BEPOTASTINE |
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