BINDING MEMBERS AGAINST IL-1R1

This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-1 and IL-1Ra for binding to IL-1R1 and binds Il-1R1 with a KD of 10 pM or less when measured by K...

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Bibliographische Detailangaben
Hauptverfasser: LOWE DAVID CHRISTOPHER, CAMPBELL JAMIE IAIN, COCHRANE DUNCAN JAMES, CRUWYS SIMON CHARLES, FINCH DONNA KIRSTY, GROVES MARIA ANASTASIA TERESA
Format: Patent
Sprache:eng ; kor
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Zusammenfassung:This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-1 and IL-1Ra for binding to IL-1R1 and binds Il-1R1 with a KD of 10 pM or less when measured by Kinexa™. The binding members are useful for, inter alia, treatment of disorders mediated by IL-1R1 including rheumatoid arthritis, asthma and chronic obstructive pulmonary disease (COPD).