PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES

PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES

The present invention relates to methods of making compounds that inhibit 11-beta-hydroxysteroid dehydrogenase type 1 enzyme (11-beta HSD1). One method comprises (a) contacting a compound of formula (II) with a chiral base, deprotonating agent, and an alkylating agent R3-LG, (b) contacting the produ...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FRIZZLE MATTHEW J, MONIZ GEORGE A, FAUL MARGARET, LARROW JAY, BERNARD CHARLES, KLINGENSMITH LIANE, MARTINELLI MICHAEL, HANSEN KARL B
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to methods of making compounds that inhibit 11-beta-hydroxysteroid dehydrogenase type 1 enzyme (11-beta HSD1). One method comprises (a) contacting a compound of formula (II) with a chiral base, deprotonating agent, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I); wherein Z, R1, R2, and R3 are defined herein.