ACETYLATION USING REDUCED VOLUME OF ACETIC ACID ANHYDRIDE FOR SYNTHESIZING NON-IONIC X-RAY CONTRAST AGENTS

PURPOSE: A method for preparing 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide is provided to reduce the amount of expensive acetic anhydride consumed per batch and to lower manufacturing costs by replacing some acetic anhydrides for inexpensive acetic acids. CONSTITUTION...

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Bibliographische Detailangaben
Hauptverfasser:	LARSEN LEIF, HOLMAAS LARS TERJE, CERVENKA JAN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	PURPOSE: A method for preparing 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide is provided to reduce the amount of expensive acetic anhydride consumed per batch and to lower manufacturing costs by replacing some acetic anhydrides for inexpensive acetic acids. CONSTITUTION: A method for preparing 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide("Compound A") uses 1.5-3.0 liter of acetic anhydrides and acetic acids as a reagent and a solvent mixture per 1 kg of 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide("Compound B") for acetylation of compound B. In acetylation, the reagent and solvent mixture are distilled and reused.