NEW SYNTHETIC METHOD OF 4,4,4-TRIFLUORO-1-(4-METHYLPHENYL) BUTANE-1,3-DIONE

NEW SYNTHETIC METHOD OF 4,4,4-TRIFLUORO-1-(4-METHYLPHENYL) BUTANE-1,3-DIONE

PURPOSE: A method for preparing 4,4,4-trifluoro-1-(4-methyl phenyl)butane-1,3-dione is provided to reduce preparation cost and to commercially prepare a large amount of the compound. CONSTITUTION: A method for preparing 4,4,4-trifluoro-1-(4-methyl phenyl)butane-1,3-dione comprises: a step of reactin...

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Bibliographische Detailangaben
Hauptverfasser: MIN, YUN SIK, SHIN, PILL SOO, CHOI, GUI YONG
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:PURPOSE: A method for preparing 4,4,4-trifluoro-1-(4-methyl phenyl)butane-1,3-dione is provided to reduce preparation cost and to commercially prepare a large amount of the compound. CONSTITUTION: A method for preparing 4,4,4-trifluoro-1-(4-methyl phenyl)butane-1,3-dione comprises: a step of reacting ethyl trifluoro acetate and ethyl acetate under the presence of base to obtain ethyl 4,4,4-trifluoro-3-oxo-butanoate; a step of reacting the resultant and hydrogen donor to obtain 4,4,4-trifluoro-3-oxo butanoic acid; a step of reacting the resultant with thiochloride; and a step of performing Friedal-Crafts acylation reaction with toluene under the presence of aluminum chloride to prepare trifluoro-1-(4-methyl phenyl)butan-1,3-dione. The hydrogen donor is trifluorocetic acid, acetic acid, propionic acid or butanoic acid.