COMPOSITION COMPRISING RAMOSETRON OR ITS SALT

COMPOSITION COMPRISING RAMOSETRON OR ITS SALT

[Problems] To provide a novel process for producing ramosetron or its salt that is useful as a pharmaceutical, especially as a therapeutic and/or preventive agent for digestive symptoms caused by administration of an anti-malignant tumor agent, diarrheal-type irritable bowel syndrome, diarrheal symp...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: INAKOSHI MASATOSHI, OHISHI YASUAKI, MARUMO KIYOTAKA, YAMAMOTO NORIYA, KIYONAGA HIROSHI
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:[Problems] To provide a novel process for producing ramosetron or its salt that is useful as a pharmaceutical, especially as a therapeutic and/or preventive agent for digestive symptoms caused by administration of an anti-malignant tumor agent, diarrheal-type irritable bowel syndrome, diarrheal symptoms of irritable bowel syndrome, etc. [Means for Resolution] Ramosetron or its salt can be produced by reacting a compound of the formula (I): [wherein X is a halogen] or a salt thereof with 1-methyl-1H-indole in the presence of a Lewis acid selected from the group consisting of a lower alkylaluminum dihalide, a di-lower alkylaluminum halide, a tri-lower alkylaluminum and a lower alkylaluminum sesquihalide.