COMPOSITION FOR TREATMENT OF NEURODEGENERATIVE DISEASES CONTAINING SPIPERONE

PURPOSE: A composition containing spiperone for treating neurogenerative disease is provided to strongly suppress inflammation with less cytotoxicity. CONSTITUTION: A composition for treating neurodegenerative disease contains spiperone. Spiperone suppresses NO generation of glial cells. Spiperone s...

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Bibliographische Detailangaben
Hauptverfasser:	HWANG, JAE GYU, ZHENG LONG TAI, SUK, KYOUNG HO, LEE, MAN GI, OCK, JI YEON, LEE, WON HA
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	PURPOSE: A composition containing spiperone for treating neurogenerative disease is provided to strongly suppress inflammation with less cytotoxicity. CONSTITUTION: A composition for treating neurodegenerative disease contains spiperone. Spiperone suppresses NO generation of glial cells. Spiperone suppresses NF-kappa B and p38 MAPK activation. The suppression inhibits expression of proinflammatory cytokine expression. The neurodegenerative diseases include Alzheimer's disease, Parkinson's disease, Lou Gehrig's disease, Huntington's disease, or senile dementia.