ADEFOVIR DIPIVOXIL HAVING A NEW CRYSTAL FORM, PREPARATION METHOD THEREOF, AND COMPOSITON FOR PREVENTING OR TREATING CHRONIC HEPATITIS B CONTAINING THE SAME AS AN ACTIVE INGREDIENT

ADEFOVIR DIPIVOXIL HAVING A NEW CRYSTAL FORM, PREPARATION METHOD THEREOF, AND COMPOSITON FOR PREVENTING OR TREATING CHRONIC HEPATITIS B CONTAINING THE SAME AS AN ACTIVE INGREDIENT

PURPOSE: An adefovir dipivoxil having novel crystalline form is provided to ensure stability and reproductivity and to prevent and treat chronic hepatitis B. CONSTITUTION: An adefovir dipivoxil of chemical formula 1 having a novel crystalline form has characteristic peal at 3.3±0.1 and 6.6±0.1. The...

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Bibliographische Detailangaben
Hauptverfasser: BYUN, YOUNG SEOK, CHUN, JONG SOO, KIM, TAE YONG, MOON, YOUNG IL, KANG, SEOK WON, KANG, HEE GEUN
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:PURPOSE: An adefovir dipivoxil having novel crystalline form is provided to ensure stability and reproductivity and to prevent and treat chronic hepatitis B. CONSTITUTION: An adefovir dipivoxil of chemical formula 1 having a novel crystalline form has characteristic peal at 3.3±0.1 and 6.6±0.1. The adefovir dipivoxil of chemical formula 1 has heating peak at 84.6 °C. A method for manufacturing the adefovir dipivoxil comprises: a step of adding adefovir dipivoxil raw ingredient in ethylformate and heating at 40-60°C to resolve; and a step of cooling the reactant at room temperature and cooling again at -25 to -20°C. A pharmaceutical composition for treating chronic hepatitis B contains adefovir dipivoxil as an active ingredient.