PROCESS FOR PRODUCTION OF 3-ALKENYLCEPHEM COMPOUNDS

PROCESS FOR PRODUCTION OF 3-ALKENYLCEPHEM COMPOUNDS

PURPOSE: A producing method of a 3-alkenylcephem compound is provided to reduce the containing rate of phenyl acetic acid or its derivative as an impurity to an E body of a target compound. CONSTITUTION: A producing method of 7-amino-3-[2-(4-methylthiazole-5-task)vinyl]-3-cephem-4-carboxylic acid ma...

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Bibliographische Detailangaben
Hauptverfasser: OOHARA NOBUHIKO, MATSUMOTO NOBUO, TAKUBO YOSUKE, WAKUI ATSUSHI
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:PURPOSE: A producing method of a 3-alkenylcephem compound is provided to reduce the containing rate of phenyl acetic acid or its derivative as an impurity to an E body of a target compound. CONSTITUTION: A producing method of 7-amino-3-[2-(4-methylthiazole-5-task)vinyl]-3-cephem-4-carboxylic acid marked as chemical formula 3, comprises the following steps: performing a de-protection reaction for an amino bond of 7 location by enzyme reacting 7-amino-3-[2-(4-methylthiazole-5-task)vinyl]-3-cephem-4-carboxylic acid salt marked as chemical formula 1; obtaining an aqueous solution of the 7-amino-3-[2-(4-methylthiazole-5-task)vinyl]-3-cephem-4-carboxylic acid or the 7 location by enzyme reacting 7-amino-3-[2-(4-methylthiazole-5-task)vinyl]-3-cephem-4-carboxylic acid salt; and reacting the aqueous solution with activated charcoal.