A POLYNUCLEOTIDE COMPRISING A UBIQUITOUS CHROMATIN OPENING ELEMENT (UCOE)

PURPOSE: A polynucleotide containing ubiquitous chromatin opening element(UCOE) is provided to promote duplication expression. CONSTITUTION: A host cell contains a vector and the vector contains polynucleotide. The polynucleotide contains unmethylated CpG-island; an expression gene which encodes des...

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Hauptverfasser: CROMBIE ROBERT, ANTONIOU MICHAEL
Format: Patent
Sprache:eng
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Zusammenfassung:PURPOSE: A polynucleotide containing ubiquitous chromatin opening element(UCOE) is provided to promote duplication expression. CONSTITUTION: A host cell contains a vector and the vector contains polynucleotide. The polynucleotide contains unmethylated CpG-island; an expression gene which encodes desired gene product; and a polynucleotide containing a promoter which is operably linked to the gene.