DIRECT METHOD FOR PREPARING CRYSTALLINE ACID-ADDED SALTS OF CEPHEM DERIVATIVES

A method for manufacturing a crystalline acid-added salt of cephem compound which is used for antibiotics is provided to easily introduce nitrogen-containing heterocyclic group and directly obtain from the acid-added salt. A method for producing a crystalline acid-added salt of cephem compound comprises: a step of reacting a cepotaxim derivative of the chemical formula 2 or its salt and heterocycle compound of R1-H under the presence of base and halogenation silyl compound to obtain the acid-added salt of cephem compound of the chemical formula 1; and a step of crystallizing the acid-added salt of cephem compound using sulphuric acid(H2SO4). The cephem compound of the chemical formula 1 is cefepime, cefpirome, or cefquinome. The base is dimethylaniline or diethylaniline. The reaction solvent is acetonitrile, dichloromethane, dimethylformamide or dimethylacetamide.