THE MANUFACTURING METHOD FOR CALDIAMIDE SODIUM

A method for manufacturing caldiamide sodium used as an MRI contrast agent industrially is provided to manufacture caldiamide sodium with high purity without problems due to remain solvents by using a freeze-drying or a spray dryer. A method for manufacturing caldiamide sodium comprises the followin...

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Hauptverfasser:	CHOI, KYUNG SEOK, KIM, YOUNG JUN, CHAE, JOO YOUNG, PARK, JUNG BUM, SHIN, SUN CHEOL, LEE, SEUNG HWA
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	A method for manufacturing caldiamide sodium used as an MRI contrast agent industrially is provided to manufacture caldiamide sodium with high purity without problems due to remain solvents by using a freeze-drying or a spray dryer. A method for manufacturing caldiamide sodium comprises the following steps of: dissolving diethylenediamine pentacetic acid bis methylamide(DTPA-BMA) in distilled water; reacting liquid after adding calcium hydroxide, calcium acetate, and methoxy calcium; reacting a reaction solution after adding sodium hydroxide, methoxy natrium, or natrium hydrid; filtering the reaction solution with a membrane filter; and crystallizing the filtered reaction solution.