MICROSPHERE FOR NASAL SPRAY COMPRISING DRUG FOR TREATING ALLERGIC RHINITIS AND PREPARATION METHOD THEREOF

A microsphere for nasal spray is provided to remove bitter taste from allergic rhinitis therapeutic agent including antihistaminic agent and to prescribe easily drug to patients that oral administration is difficult and to obtain bioequivalence similar to oral preparations from allergic rhinitis therapeutic agent including normal antihistaminic agent. A microsphere for nasal spray comprises allergic rhinitis therapeutic agent 10-20 weight%, adhesive polymer 60-80 weight%, emission controlling agent 1-10 weight% and bile salts 1-15 weight%. The adhesive polymer is one selected from a group consisting of hyaluronic acid, gelatin, collagen, chitosan, polyacrylic acid and cellulose derivative. The emission controlling agent is one selected from a group consisting of polyethylene glycol, mannitol and Bovine Serum albumin.