2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES AS INHIBITORS OF PROTEIN KINASE C-ALPHA

The present invention relates to 2-arylamino-4-(heterocyclic)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-a). The PKC-a inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improve...

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Bibliographische Detailangaben
Hauptverfasser: DJUNG JANE FAR JINE, GOLEBIOWSKI ADAM, SHRUM GARY P, HUNTER JACK A
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to 2-arylamino-4-(heterocyclic)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-a). The PKC-a inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4-(heterocyclic)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.