PROCESS FOR PRODUCTION OF INDENE DERIVATIVE, AND INTERMEDIATE FOR PRODUCTION OF THE DERIVATIVE

PROCESS FOR PRODUCTION OF INDENE DERIVATIVE, AND INTERMEDIATE FOR PRODUCTION OF THE DERIVATIVE

An indene derivative can be used as an intermediated for the synthesis of a vitamin D2 derivative paricalcitol which is useful as a pharmaceutical. The indene derivative can be produced with high efficiency by subjecting a vitamin D2 derivative such as 25-hydroxyvitamin D2 to a two-stage oxidation r...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: TOYODA ASAKO, NAGAI HAZUKI
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An indene derivative can be used as an intermediated for the synthesis of a vitamin D2 derivative paricalcitol which is useful as a pharmaceutical. The indene derivative can be produced with high efficiency by subjecting a vitamin D2 derivative such as 25-hydroxyvitamin D2 to a two-stage oxidation reaction in a proper solvent such as methanol and ethanol using an oxidizing agent such as potassium permanganate and sodium periodate.