SOLID FORMULATION FOR MEDICINE COMPRISING SPARINGLY SOLUBLE DRUG AND PROCESS FOR PREPARING THE SAME

A method for preparing an enteric solid preparation is provided to produce the enteric solid preparation having improved dissolution of a poorly soluble drug conveniently using an existing equipment without using an organic solvent. To prepare an enteric solid preparation, a core particle is coated...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	NISHIYAMA YUICHI, TANNO FUMIE
Format:	Patent
Sprache:	eng
Schlagworte:	BABY COMFORTERS CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY DEVICES FOR RECEIVING SPITTLE DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A method for preparing an enteric solid preparation is provided to produce the enteric solid preparation having improved dissolution of a poorly soluble drug conveniently using an existing equipment without using an organic solvent. To prepare an enteric solid preparation, a core particle is coated with a powder enteric coating agent while spraying a plasticizer comprising a poorly soluble drug dissolved therein, wherein the plasticizer is ethyl citrate or polyethylene glycol, and the enteric coating agent has an average particle diameter of less than 10 micrometers and comprises a compound selected from the group consisting of hydroxypropylmethylcellulose acetate succinate, hydroxypropylmethylcellulose trimellitate, and hydroxypropylmethylcellulose acetate maleate.