THERMOGELLING POLY(ETHYLENE GLYCOL)/POLYPEPTIDE BLOCK COPOLYMER AQUEOUS SOLUTION, PREPARATION METHOD THEREOF AND THEIR BIOMEDICAL APPLICATIONS

A temperature sensitive sol-gel transfer polyethylene glycol/polypeptide block copolymer, and a method for preparing the polyethylene glycol/polypeptide block copolymer are provided to improve the drug delivery efficiency by the transfer of the block copolymer from an aqueous solution to a hydrated...

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Bibliographische Detailangaben
Hauptverfasser:	JEONG, BYEONG MOON, JEONG, YU RI, BAHK, KYUNG HYUN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS BASED THEREON DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	A temperature sensitive sol-gel transfer polyethylene glycol/polypeptide block copolymer, and a method for preparing the polyethylene glycol/polypeptide block copolymer are provided to improve the drug delivery efficiency by the transfer of the block copolymer from an aqueous solution to a hydrated gel at a specific temperature. A polyethylene glycol/polypeptide block copolymer comprises 40-80 wt% of a polyethylene glycol block having a number average molecular weight of 400-6,000 Dalton and 20-70 wt% of a polypeptide block having a number average molecular weight of 200-2,000 Dalton, and has a molecular weight of 500-30,000. Preferably the polyethylene glycol/polypeptide block copolymer has a structure of a polyethylene glycol-polypeptide, a polyethylene glycol,-polypeptide-polyethylene glycol, a polypeptide-polyethylene glycol-polyethylene glycol-polypeptide, or a (polyethylene glycol-polypeptide)n, wherein n is an integer of 2-30.