BENZOIC ACID DERIVATIVES THAT ARE MODULATORS OR AGONISTS OF GLYR

Compounds of formula I, wherein Y = H,-OH, halo,-OC1-6 alkyl,-C1-6alkyl, the two latter optionally substituted with halo,-CN,-OH,-CF3,-NH2; Rl =-C3-6 cycloaUcyl, heterocycloalkyl, aryl, alkylaryl, heteroaryl,-C3-6-alkyl, optionally substituted with halo,-CN,-OH,-CF3,-OCF3,-NH2,-CONH2; M =-C(O)-,-C(H2)-,-CH(OR3)-,-N(Ra)-,-S(O) r-, heteroaryl and a bond; wherein Ra = H or C1-6alkyl and r = 0, 1 or 2; R2 = H, halo,-CN, or D =-C1-6 alkyl, C3-6cycloalkyl, heterocycloalkyl,-N(CH3) 2, aryl, alkylaryl, heteroaryl, and heterocyclic groups; where D is optionally substituted with G = halo,-NO2,-CN,-OH,-CF3,-OCF3,-NH2,-CONH2,-COOH, aryl, heteroaryl, heterocyclic groups,-C1-6alkyl,-C1-6alkoxy, heterocycloalkyl, and C1-6 alkylcarboxylate; where D may be connected to G by L =-C(O)-,-S-, or-S(O2)-; and G may be further substituted with substituents selected from halo,-NO2,-CN,-OH,-CH3,-OCH 3,-CF3,-OCF3,-NH2,-CONH 2,-COOH, C1-6alkylcarboxylate; and R3 =-OH or C1-6alkoxy.