A PROCESS FOR PREPARATION OF L-ALPHA-GLYCEROPHOSPHORYL CHOLINE

A PROCESS FOR PREPARATION OF L-ALPHA-GLYCEROPHOSPHORYL CHOLINE

A process for preparation of L-alpha-glycerophosphoryl choline is provided to reduce preparation costs by using an inexpensive starting material and a small amount of ion exchange resin, improve preparation yield and is applied to the industrial scale. A process for preparation of L-alpha-glyceropho...

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Hauptverfasser: MOON, SEONG CHEOL, KANG, PHIL GOO, LEE, BYUNG GOO, SONG, YOON SEOK, KANG, DOO SUNG, SONG, EUN SEOB, SONG, IN WOONG, OH, SEONG SOO
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:A process for preparation of L-alpha-glycerophosphoryl choline is provided to reduce preparation costs by using an inexpensive starting material and a small amount of ion exchange resin, improve preparation yield and is applied to the industrial scale. A process for preparation of L-alpha-glycerophosphoryl choline represented by the formula(1) comprises the steps of: removing calcium from compounds represented by the formula(2) under acid condition at -10 to 60 deg.C and pH 2 or less to prepare compounds represented by the formula(3); reacting the compounds represented by the formula(3) with compounds represented by the formula(4) in solvent selected from C1-C6 alcohol, C1-C6 ether, C1-C6 ketone and a mixture thereof at 40-120 deg.C and pH 5-10 to prepare compounds represented by the formula(5); crystallizing the compounds represented by the formula(5) by using a crystallizing agent selected from C1-C6 alcohol, C1-C6 ketone and a mixture thereof at 0-25 deg.C; and subjecting the compounds represented by the formula(5) to ion exchange resin so as to remove chlorine ion.