AZOLYLACYLGUANIDINES AS beta;-SECRETASE INHIBITORS

AZOLYLACYLGUANIDINES AS beta;-SECRETASE INHIBITORS

The present invention provides an azolylacylquanidine compound of formula (I). The present invention also provides methods for the use thereof to inhibit F-secretase (BACE) and treat F-amyloid deposits and neurofibrillary tangles.

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Bibliographische Detailangaben
Hauptverfasser: LOVERING FRANK ELDRIDGE, MOORE WILLIAM JAY, CONDON JEFFREY SCOTT, STOCK JOSEPH RAYMOND, ZHOU PING, COLE DEREK CECIL, WU JUNJUN, JENNINGS LEE DALTON, MANAS ERIC STEVEN, SUKHDEO MOHANI NIRMALA, ELLINGBOE JOHN WATSON, MORRIS KOI MICHELE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention provides an azolylacylquanidine compound of formula (I). The present invention also provides methods for the use thereof to inhibit F-secretase (BACE) and treat F-amyloid deposits and neurofibrillary tangles.