NEW 3-PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR-GAMMA REZEPTOR LIGANDEN

NEW 3-PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR-GAMMA REZEPTOR LIGANDEN

The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or-COO-C1-C4-alkyl group; Y represents NH, N-C1-C10-alkyl, O, or S; Z represents NH, N-C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH,...

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Hauptverfasser: MAJKA ZBIGNIEW, STAWINSKI TOMASZ, RUSIN KATARZYNA, KUROWSKI KRZYSZTOF, KLUDKIEWICZ DOMINIK, MATUSIEWICZ KATARZYNA, KOWALCZYK PIOTR, SULIKOWSKI DANIEL
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or-COO-C1-C4-alkyl group; Y represents NH, N-C1-C10-alkyl, O, or S; Z represents NH, N-C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N-C1-C10-alkyl, N-aryl, NSO2-C1-C10-alkyl, N-SO2-aryl, or N-SO2-heteroaryl; R1 to R6 each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments.