A METHOD FOR PREPARING LOW MOLECULAR WEIGHT POLYSACCHARIDE AND THE SALT THEREOF
Provided is a method for preparing a low molecular weight polysaccharide having a molecular weight of 500-50,000 and its salt to prevent the generation of by-products and to lower a manufacturing cost. The method comprises the step of hydrolyzing a hyaluronic acid of high molecular weight in an aque...
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| creator | CHOI, BONG RAK KIM, YOUNG HEUI KIM, KI HO KIM, KI SU RYU, HEE JONG KIM, JIN GUK JO, NAM SUK |
| description | Provided is a method for preparing a low molecular weight polysaccharide having a molecular weight of 500-50,000 and its salt to prevent the generation of by-products and to lower a manufacturing cost. The method comprises the step of hydrolyzing a hyaluronic acid of high molecular weight in an aqueous solution or a mixture solvent by using an ion exchange resin. Preferably the low molecular weight polysaccharide and its salt are represented by the formula I, wherein n is an integer of 1-120; and R is H or a pharmaceutically acceptable salt. Preferably the method comprises the steps of dissolving a hyaluronic acid sodium salt of high molecular weight in water or a mixture solvent of water and a low molecular weight alcohol; adding 0.01-50 % of ion exchange resin and stirring the mixture at 20-100 deg.C for 24-120 hours; and filtering it to remove the ion exchange resin and freeze-drying the solution. |
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The method comprises the step of hydrolyzing a hyaluronic acid of high molecular weight in an aqueous solution or a mixture solvent by using an ion exchange resin. Preferably the low molecular weight polysaccharide and its salt are represented by the formula I, wherein n is an integer of 1-120; and R is H or a pharmaceutically acceptable salt. Preferably the method comprises the steps of dissolving a hyaluronic acid sodium salt of high molecular weight in water or a mixture solvent of water and a low molecular weight alcohol; adding 0.01-50 % of ion exchange resin and stirring the mixture at 20-100 deg.C for 24-120 hours; and filtering it to remove the ion exchange resin and freeze-drying the solution.</description><language>eng</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; DERIVATIVES THEREOF ; FOODS OR FOODSTUFFS ; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J ; HUMAN NECESSITIES ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; POLYSACCHARIDES ; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL ; THEIR PREPARATION OR CHEMICAL WORKING-UP ; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070102&DB=EPODOC&CC=KR&NR=20070000057A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070102&DB=EPODOC&CC=KR&NR=20070000057A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHOI, BONG RAK</creatorcontrib><creatorcontrib>KIM, YOUNG HEUI</creatorcontrib><creatorcontrib>KIM, KI HO</creatorcontrib><creatorcontrib>KIM, KI SU</creatorcontrib><creatorcontrib>RYU, HEE JONG</creatorcontrib><creatorcontrib>KIM, JIN GUK</creatorcontrib><creatorcontrib>JO, NAM SUK</creatorcontrib><title>A METHOD FOR PREPARING LOW MOLECULAR WEIGHT POLYSACCHARIDE AND THE SALT THEREOF</title><description>Provided is a method for preparing a low molecular weight polysaccharide having a molecular weight of 500-50,000 and its salt to prevent the generation of by-products and to lower a manufacturing cost. The method comprises the step of hydrolyzing a hyaluronic acid of high molecular weight in an aqueous solution or a mixture solvent by using an ion exchange resin. Preferably the low molecular weight polysaccharide and its salt are represented by the formula I, wherein n is an integer of 1-120; and R is H or a pharmaceutically acceptable salt. Preferably the method comprises the steps of dissolving a hyaluronic acid sodium salt of high molecular weight in water or a mixture solvent of water and a low molecular weight alcohol; adding 0.01-50 % of ion exchange resin and stirring the mixture at 20-100 deg.C for 24-120 hours; and filtering it to remove the ion exchange resin and freeze-drying the solution.</description><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>DERIVATIVES THEREOF</subject><subject>FOODS OR FOODSTUFFS</subject><subject>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</subject><subject>HUMAN NECESSITIES</subject><subject>METALLURGY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>POLYSACCHARIDES</subject><subject>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><subject>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</subject><subject>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirEKwjAQQLM4iPoPB85CUKTzkVyaYtoL15TiVIrESbRQ_x8t-AG-5b3hrRUj1JQ8W3AsEIUiStWUELiHmgOZLqBAT1XpE0QO1xaN8d_HEmBjIXmCFkNaQojdVq3u42POu583au8oGX_I02vI8zTe8jO_h4sctS70wrnA03_XB9nxL0s</recordid><startdate>20070102</startdate><enddate>20070102</enddate><creator>CHOI, BONG RAK</creator><creator>KIM, YOUNG HEUI</creator><creator>KIM, KI HO</creator><creator>KIM, KI SU</creator><creator>RYU, HEE JONG</creator><creator>KIM, JIN GUK</creator><creator>JO, NAM SUK</creator><scope>EVB</scope></search><sort><creationdate>20070102</creationdate><title>A METHOD FOR PREPARING LOW MOLECULAR WEIGHT POLYSACCHARIDE AND THE SALT THEREOF</title><author>CHOI, BONG RAK ; KIM, YOUNG HEUI ; KIM, KI HO ; KIM, KI SU ; RYU, HEE JONG ; KIM, JIN GUK ; JO, NAM SUK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20070000057A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>DERIVATIVES THEREOF</topic><topic>FOODS OR FOODSTUFFS</topic><topic>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</topic><topic>HUMAN NECESSITIES</topic><topic>METALLURGY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>POLYSACCHARIDES</topic><topic>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><topic>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><toplevel>online_resources</toplevel><creatorcontrib>CHOI, BONG RAK</creatorcontrib><creatorcontrib>KIM, YOUNG HEUI</creatorcontrib><creatorcontrib>KIM, KI HO</creatorcontrib><creatorcontrib>KIM, KI SU</creatorcontrib><creatorcontrib>RYU, HEE JONG</creatorcontrib><creatorcontrib>KIM, JIN GUK</creatorcontrib><creatorcontrib>JO, NAM SUK</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHOI, BONG RAK</au><au>KIM, YOUNG HEUI</au><au>KIM, KI HO</au><au>KIM, KI SU</au><au>RYU, HEE JONG</au><au>KIM, JIN GUK</au><au>JO, NAM SUK</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A METHOD FOR PREPARING LOW MOLECULAR WEIGHT POLYSACCHARIDE AND THE SALT THEREOF</title><date>2007-01-02</date><risdate>2007</risdate><abstract>Provided is a method for preparing a low molecular weight polysaccharide having a molecular weight of 500-50,000 and its salt to prevent the generation of by-products and to lower a manufacturing cost. The method comprises the step of hydrolyzing a hyaluronic acid of high molecular weight in an aqueous solution or a mixture solvent by using an ion exchange resin. Preferably the low molecular weight polysaccharide and its salt are represented by the formula I, wherein n is an integer of 1-120; and R is H or a pharmaceutically acceptable salt. Preferably the method comprises the steps of dissolving a hyaluronic acid sodium salt of high molecular weight in water or a mixture solvent of water and a low molecular weight alcohol; adding 0.01-50 % of ion exchange resin and stirring the mixture at 20-100 deg.C for 24-120 hours; and filtering it to remove the ion exchange resin and freeze-drying the solution.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL THEIR PREPARATION OR CHEMICAL WORKING-UP THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES |
| title | A METHOD FOR PREPARING LOW MOLECULAR WEIGHT POLYSACCHARIDE AND THE SALT THEREOF |
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