A METHOD FOR PREPARING LOW MOLECULAR WEIGHT POLYSACCHARIDE AND THE SALT THEREOF

Provided is a method for preparing a low molecular weight polysaccharide having a molecular weight of 500-50,000 and its salt to prevent the generation of by-products and to lower a manufacturing cost. The method comprises the step of hydrolyzing a hyaluronic acid of high molecular weight in an aque...

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Bibliographische Detailangaben
Hauptverfasser:	CHOI, BONG RAK, KIM, YOUNG HEUI, KIM, KI HO, KIM, KI SU, RYU, HEE JONG, KIM, JIN GUK, JO, NAM SUK
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL THEIR PREPARATION OR CHEMICAL WORKING-UP THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	Provided is a method for preparing a low molecular weight polysaccharide having a molecular weight of 500-50,000 and its salt to prevent the generation of by-products and to lower a manufacturing cost. The method comprises the step of hydrolyzing a hyaluronic acid of high molecular weight in an aqueous solution or a mixture solvent by using an ion exchange resin. Preferably the low molecular weight polysaccharide and its salt are represented by the formula I, wherein n is an integer of 1-120; and R is H or a pharmaceutically acceptable salt. Preferably the method comprises the steps of dissolving a hyaluronic acid sodium salt of high molecular weight in water or a mixture solvent of water and a low molecular weight alcohol; adding 0.01-50 % of ion exchange resin and stirring the mixture at 20-100 deg.C for 24-120 hours; and filtering it to remove the ion exchange resin and freeze-drying the solution.