PHARMACEUTICAL FORMULATIONS FOR THE SUSTAINED RELEASE OF INTERLEUKINS AND THERAPEUTIC APPLICATIONS THEREOF

The invention relates to novel pharmaceutical formulations based on fluids and stable aqueous colloidal suspensions for the sustained release of an interleukin IL- (and one or more other optional active principles), and to the applications, particularly the therapeutic applications, of said formulations. According to the invention, the formulation is a low-viscosity aqueous colloidal suspension of submicronic particles of water-soluble, biodegradable polymer PO bearing hydrophobic groups (GH). The aforementioned particles are noncovalently associated with at least one interleukin (and one or more other optional active principles) and form a gelled deposit on the injection site, said gelling being caused by a protein present in the physiological medium.