PROCESS FOR PREPARING 5-(4-FLUOROPHENYL)-1-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)ETHYL]-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE

PROCESS FOR PREPARING 5-(4-FLUOROPHENYL)-1-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)ETHYL]-2-ISOPROPYL-4-PHENYL-1H-PYRROLE-3-CARBOXYLIC ACID PHENYLAMIDE

A method for preparing 5-(4-fluorophenyl)- 1-[2R,4R)-4- hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4- phenyl-1H-pyrrole-3-carboxylic acid phenylamide (I), a key intermediate in the synthesis of atorvastatin calcium, is described.

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Bibliographische Detailangaben
Hauptverfasser: NELSON JADE DOUGLAS, PAMMENT MICHAEL GERARD
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A method for preparing 5-(4-fluorophenyl)- 1-[2R,4R)-4- hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4- phenyl-1H-pyrrole-3-carboxylic acid phenylamide (I), a key intermediate in the synthesis of atorvastatin calcium, is described.