PROCESS FOR OBTAINING 17alpha-ACETOXY-11beta-(4,N,N-DIMETHYLAMINOPHENYL)-19-NORPREGNA-4,9-DIENE-3,20-DIONE

PROCESS FOR OBTAINING 17alpha-ACETOXY-11beta-(4,N,N-DIMETHYLAMINOPHENYL)-19-NORPREGNA-4,9-DIENE-3,20-DIONE

The invention relates to a method of obtaining 17alpha-acetoxy- 11beta-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione. The inventive method consists in: (a) forming crystals of the isopropanol hemisolvate of 17alpha-acetoxy-11beta-(4-N,N-dimethylaminophenyl)-19- norpregna-4,9-diene-3,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SILVA GUISASOLA LUIS OCTAVIO, GUTIERREZ FUENTES LUIS GERARDO, ROSON NINO CARLOS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to a method of obtaining 17alpha-acetoxy- 11beta-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione. The inventive method consists in: (a) forming crystals of the isopropanol hemisolvate of 17alpha-acetoxy-11beta-(4-N,N-dimethylaminophenyl)-19- norpregna-4,9-diene-3,20-dione (VA-2914), by means of dissolution in isopropanol followed by crystallisation; (b) separating the VA-2914 isopropanol hemisolvate crystals; and (c) converting said VA-2914 isopropanol hemisolvate into VA-2914. Compound VA-2914 is a steroid with anti-progestational and anti-glucocorticoid activity, which can be used in therapeutic gynaecological and contraceptive indications and in the treatment of Cushing syndrome and glaucoma.