PREPARATION METHOD OF ENTERIC AQUEOUS DISPERSED HYDROXYPROPYL METHYLCELLULOSE PHTHALATE NANOPARTICLE

A process is provided to produce enteric aqueous dispersed hydroxypropyl methylcellulose phthalate nanoparticles excellent in a film property and an enteric coating property, which dose not use a high-priced emulsifier, shortens time of an ion exchange process, and uses a plasticizer after the ion e...

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Bibliographische Detailangaben
Hauptverfasser:	KIM, IL HYUK, YEO, KWANG SOO, PARK, YOUNG JU, KIM, JUNG HYUN, LEE, KYUNG WON, BAEK, HYUN HO
Format:	Patent
Sprache:	eng
Schlagworte:	ADHESIVES AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G CHEMICAL PAINT OR INK REMOVERS CHEMISTRY COATING COMPOSITIONS, e.g. PAINTS, VARNISHES ORLACQUERS COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS CORRECTING FLUIDS DERIVATIVES THEREOF DYES FILLING PASTES GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HYGIENE INKS MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS NATURAL RESINS ORGANIC MACROMOLECULAR COMPOUNDS PAINTS PASTES OR SOLIDS FOR COLOURING OR PRINTING POLISHES POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP USE OF MATERIALS THEREFOR WOODSTAINS WORKING-UP
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Zusammenfassung:	A process is provided to produce enteric aqueous dispersed hydroxypropyl methylcellulose phthalate nanoparticles excellent in a film property and an enteric coating property, which dose not use a high-priced emulsifier, shortens time of an ion exchange process, and uses a plasticizer after the ion exchange process. The process comprises the steps of: injecting a neutralizing agent into hydroxypropyl methylcellulose phthalate to prepare nanoparticles having the residual electrolyte content of 10.0-12.0mS; ion-exchanging the nanoparticles to have the residual electrolyte content of 7.0-9.0mS; adding the plasticizer to the ion-exchanged nanoparticles to soften. The neutralizing agent is ammonia water. And the plasticizer is selected from polyvinyl alcohol, polyethylene glycol, glycerine, propylene glycol, diethyl phthalate, triacetin, cetyl alcohol, triethyl citrate, and a hydrophilic plasticizer.