COMPOSITION OF PACLITAXEL INJECTION HAVING IMPROVED CELL MEMBRANE PERMEABILITY AND EXCELLENT ANTICANCER EFFICACY

COMPOSITION OF PACLITAXEL INJECTION HAVING IMPROVED CELL MEMBRANE PERMEABILITY AND EXCELLENT ANTICANCER EFFICACY

PURPOSE: Provided is a composition of paclitaxel injection which has high solubility of drugs and extended storage as well as improved cell membrane permeability and excellent anticancer efficacy. CONSTITUTION: The composition of paclitaxel injection having improved cell membrane permeability is cha...

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Bibliographische Detailangaben
Hauptverfasser: SUNWOO, SUN, KIL, JOON HYUNG, LEE, GEONG GUEN, BYUN, KEUN SOO, CHUNG, ICK SOO, CHUNG, KYU NUNG, KANG, HOON SERG, YUN, YOUNG HOON
Format: Patent
Sprache:eng ; kor
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:PURPOSE: Provided is a composition of paclitaxel injection which has high solubility of drugs and extended storage as well as improved cell membrane permeability and excellent anticancer efficacy. CONSTITUTION: The composition of paclitaxel injection having improved cell membrane permeability is characterized by comprising 0.0001-10 wt.% of paclitaxel, 30-49.999 wt.% of solubilizing agent selected from (oxyethylene)l sorbitol (olate)m or (oxyethylene)l sorbitan (olate)m, wherein l is an integer of 15-60 and m is an integer of 1-4, 0.0001-30 wt.% of cell membrane permeability-improving agent selected from conjugated linoleic acid phosphatidyl choline and docosahexaenoic acid phosphatidyl choline, and 30-49.999 wt.% of anhydrous alcohol selected from anhydrous ethanol, anhydrous isopropylalcohol, anhydrous-n-propylalcohol and t-butylalcohol.