ANTI-CARCINOGENIC VITAMIN D3 ANALOGS WHICH MINIMIZES ADVERSE SIDE EFFECT

PURPOSE: Anti-carcinogenic vitamin D3 analogs are provided, which have high anti-carcinogenic activity and do not result in high calcium concentration in a cell. CONSTITUTION: The anti-carcinogenic vitamin D3 analogs represented by the formula(1) are provided, wherein R is C4-C20 carbon optionally s...

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Bibliographische Detailangaben
Hauptverfasser:	LEE, YEONG YEOL, KIM, HYEONG JIN, CHO, CHEON GYU
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Zusammenfassung:	PURPOSE: Anti-carcinogenic vitamin D3 analogs are provided, which have high anti-carcinogenic activity and do not result in high calcium concentration in a cell. CONSTITUTION: The anti-carcinogenic vitamin D3 analogs represented by the formula(1) are provided, wherein R is C4-C20 carbon optionally substituted with hydroxy containing double bond. An anti-carcinogenic drug comprises the anti-carcinogenic vitamin D3 analogs of the formula(1) or pharmaceutically acceptable salts thereof. The method for preparing the anti-carcinogenic vitamin D3 analogs of the formula(1) comprises the steps of: reacting a phosphine oxide compound of the formula(2) with a ketone compound of the formula(3) to prepare a compound of the formula(4); and removing a protecting group from the compound of the formula(4), wherein Pro is an amine protecting group.