Thione derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
PURPOSE: A thione derivative, a processes for preparing the same, and a pharmaceutical composition containing the same are provided, which compound has fever removing, pain alleviating and anti-inflammatory effects. CONSTITUTION: A thione derivative is represented by the formula(1), wherein A and B...
Gespeichert in:
Hauptverfasser: | , , , , , , , , , , , , |
---|---|
Format: | Patent |
Sprache: | eng ; kor |
Schlagworte: | |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | PURPOSE: A thione derivative, a processes for preparing the same, and a pharmaceutical composition containing the same are provided, which compound has fever removing, pain alleviating and anti-inflammatory effects. CONSTITUTION: A thione derivative is represented by the formula(1), wherein A and B are independently O, S, NR2; R2 is hydrogen, C1-C4 alkyl, C1-C4 alkenyl, or aryl; Ar is aryl, heteroaryl, or aryl or heteroaryl substituted 1 to 5 substituents selected from C1-C4 alkyl, C1-C4 alkoxy, halogen, trifluoromethyl, nitro, acetoxy, amine, C1-C3 alkyl amine, C1-C3 dialkylamine, hydroxy, C1-C3 hydroxy alkyl and thioxy; and R1 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, halogen, cyano, nitro, hydroxy, amino, C1-C4 alkylamino or di-C1-C4 alkylamino. a method for preparing the thione derivative of the formula(1) or nontoxic salts thereof comprises reacting propionic acid derivative of the formula(2) with phosphorus pentasulfide, Lawesson's reagent, beta-oxothionic acid or beta-oxothionic acid potassium salt, wherein R3 is C1-C4 alkyl.
본 발명은 하기 화학식 1로 표시되는 티온 유도체 또는 그의 무독성 염을 제공한다. 본 발명에 따르면 해열, 진통, 소염작용을 가지며 부작용이 개선된 티온 유도체 또는 그의 무독성 염 및 이들의 제조방법 그리고 이들을 함유한 약제학적 조성물을 제공할 수 있다. |
---|