Thione derivatives processes for the preparation thereof and pharmaceutical compositions containing the same

PURPOSE: A thione derivative, a processes for preparing the same, and a pharmaceutical composition containing the same are provided, which compound has fever removing, pain alleviating and anti-inflammatory effects. CONSTITUTION: A thione derivative is represented by the formula(1), wherein A and B...

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Hauptverfasser: PARK, HYEON JEONG, KIM, JONG HUN, PARK, JI EUN, CHAE, MYEONG YUN, KIM, YEONG HUN, NOH, JI YEONG, PARK, SANG UK, JUNG, YEONG MI, JUNG, SEONG HAK, YOEN, GYU JEONG, RYU, CHUN SEON, CHO, IL HWAN, YOO, HYEONG CHEOL
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Sprache:eng ; kor
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Zusammenfassung:PURPOSE: A thione derivative, a processes for preparing the same, and a pharmaceutical composition containing the same are provided, which compound has fever removing, pain alleviating and anti-inflammatory effects. CONSTITUTION: A thione derivative is represented by the formula(1), wherein A and B are independently O, S, NR2; R2 is hydrogen, C1-C4 alkyl, C1-C4 alkenyl, or aryl; Ar is aryl, heteroaryl, or aryl or heteroaryl substituted 1 to 5 substituents selected from C1-C4 alkyl, C1-C4 alkoxy, halogen, trifluoromethyl, nitro, acetoxy, amine, C1-C3 alkyl amine, C1-C3 dialkylamine, hydroxy, C1-C3 hydroxy alkyl and thioxy; and R1 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, halogen, cyano, nitro, hydroxy, amino, C1-C4 alkylamino or di-C1-C4 alkylamino. a method for preparing the thione derivative of the formula(1) or nontoxic salts thereof comprises reacting propionic acid derivative of the formula(2) with phosphorus pentasulfide, Lawesson's reagent, beta-oxothionic acid or beta-oxothionic acid potassium salt, wherein R3 is C1-C4 alkyl. 본 발명은 하기 화학식 1로 표시되는 티온 유도체 또는 그의 무독성 염을 제공한다. 본 발명에 따르면 해열, 진통, 소염작용을 가지며 부작용이 개선된 티온 유도체 또는 그의 무독성 염 및 이들의 제조방법 그리고 이들을 함유한 약제학적 조성물을 제공할 수 있다.