Extraction and purification method of constituents from stem of Lonicera japonica Thunb. and the constituents of injection drug
PURPOSE: Provided is a method of extracting and purifying the effective active components from the aerial parts of Lonicera japonica which involves enhanced solubility and blood safety with excellent painkilling and anti-inflammatory effects. CONSTITUTION: The method of extracting and purifying the...
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| creator | HAN, CHANG GYUN CHO, YONG BAEK LEE, HAE IN KWAK, UI JONG RYU, GEUN HO SHIN, HUI JAE YOO, HEON SEUNG |
| description | PURPOSE: Provided is a method of extracting and purifying the effective active components from the aerial parts of Lonicera japonica which involves enhanced solubility and blood safety with excellent painkilling and anti-inflammatory effects. CONSTITUTION: The method of extracting and purifying the effective active components from the aerial parts of Lonicera japonica comprises the steps of: reflux-extracting the aerial parts of Lonicera japonica with water, and filtering it; adding the same amount of water-saturated short chain alcohol to isolate a layer; vacuum concentrating the alcohol layer to form a powder extract; purifying the extract with polyamide resin or polyvinylpyrrolidone resin; and purifying it with octadecylsilane. The short chain alcohol is butyl alcohol or propyl alcohol. The effective active components are sweroside and loganin.
본 발명은 인동등(인동잎을 제거한 인동줄기, 이하 인동등)으로부터 유효활성성분을 추출, 정제하는 방법 및 그 유효활성성분을 함유한 주사제 조성물에 관한 것으로서, 더욱 상세하게는 인동등으로부터 불필요한 탄닌과 난용성 플라보노이드, 사포닌 등의 성분을 제거하여 주사제 원료로 사용시 약효가 우수하며 그 유효성, 안전성 및 안정성이 뛰어난 스웨로사이드(sweroside), 로가닌(loganin)과 같은 이리도이드(iridoid)계 물질을 주성분으로 함유한 유효활성성분을 추출, 정제하는 방법 및 그 유효활성성분을 함유한 소염, 진통 주사제 조성물에 관한 것이다. |
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본 발명은 인동등(인동잎을 제거한 인동줄기, 이하 인동등)으로부터 유효활성성분을 추출, 정제하는 방법 및 그 유효활성성분을 함유한 주사제 조성물에 관한 것으로서, 더욱 상세하게는 인동등으로부터 불필요한 탄닌과 난용성 플라보노이드, 사포닌 등의 성분을 제거하여 주사제 원료로 사용시 약효가 우수하며 그 유효성, 안전성 및 안정성이 뛰어난 스웨로사이드(sweroside), 로가닌(loganin)과 같은 이리도이드(iridoid)계 물질을 주성분으로 함유한 유효활성성분을 추출, 정제하는 방법 및 그 유효활성성분을 함유한 소염, 진통 주사제 조성물에 관한 것이다.</description><edition>7</edition><language>eng ; kor</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040318&DB=EPODOC&CC=KR&NR=20040023392A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040318&DB=EPODOC&CC=KR&NR=20040023392A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HAN, CHANG GYUN</creatorcontrib><creatorcontrib>CHO, YONG BAEK</creatorcontrib><creatorcontrib>LEE, HAE IN</creatorcontrib><creatorcontrib>KWAK, UI JONG</creatorcontrib><creatorcontrib>RYU, GEUN HO</creatorcontrib><creatorcontrib>SHIN, HUI JAE</creatorcontrib><creatorcontrib>YOO, HEON SEUNG</creatorcontrib><title>Extraction and purification method of constituents from stem of Lonicera japonica Thunb. and the constituents of injection drug</title><description>PURPOSE: Provided is a method of extracting and purifying the effective active components from the aerial parts of Lonicera japonica which involves enhanced solubility and blood safety with excellent painkilling and anti-inflammatory effects. CONSTITUTION: The method of extracting and purifying the effective active components from the aerial parts of Lonicera japonica comprises the steps of: reflux-extracting the aerial parts of Lonicera japonica with water, and filtering it; adding the same amount of water-saturated short chain alcohol to isolate a layer; vacuum concentrating the alcohol layer to form a powder extract; purifying the extract with polyamide resin or polyvinylpyrrolidone resin; and purifying it with octadecylsilane. The short chain alcohol is butyl alcohol or propyl alcohol. The effective active components are sweroside and loganin.
본 발명은 인동등(인동잎을 제거한 인동줄기, 이하 인동등)으로부터 유효활성성분을 추출, 정제하는 방법 및 그 유효활성성분을 함유한 주사제 조성물에 관한 것으로서, 더욱 상세하게는 인동등으로부터 불필요한 탄닌과 난용성 플라보노이드, 사포닌 등의 성분을 제거하여 주사제 원료로 사용시 약효가 우수하며 그 유효성, 안전성 및 안정성이 뛰어난 스웨로사이드(sweroside), 로가닌(loganin)과 같은 이리도이드(iridoid)계 물질을 주성분으로 함유한 유효활성성분을 추출, 정제하는 방법 및 그 유효활성성분을 함유한 소염, 진통 주사제 조성물에 관한 것이다.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNTT0LwjAQ7eIg6n84cFZC6-IoUhF0ku7lTC82xV5CcgE3_7q2urg5vcf7nGbP8iEBtVjHgNyAT8Eaq3EUepLWNeAMaMdRrCRiiWCC6yEK9YNzdmw1BYQO_UARqjbxdT2uSUu_1XfBckefvyak2zybGLxHWnxxli0PZbU_rsi7mqJHTUxSny65Uhul8qLY5rviv9QLVY5KEg</recordid><startdate>20040318</startdate><enddate>20040318</enddate><creator>HAN, CHANG GYUN</creator><creator>CHO, YONG BAEK</creator><creator>LEE, HAE IN</creator><creator>KWAK, UI JONG</creator><creator>RYU, GEUN HO</creator><creator>SHIN, HUI JAE</creator><creator>YOO, HEON SEUNG</creator><scope>EVB</scope></search><sort><creationdate>20040318</creationdate><title>Extraction and purification method of constituents from stem of Lonicera japonica Thunb. and the constituents of injection drug</title><author>HAN, CHANG GYUN ; CHO, YONG BAEK ; LEE, HAE IN ; KWAK, UI JONG ; RYU, GEUN HO ; SHIN, HUI JAE ; YOO, HEON SEUNG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20040023392A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2004</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HAN, CHANG GYUN</creatorcontrib><creatorcontrib>CHO, YONG BAEK</creatorcontrib><creatorcontrib>LEE, HAE IN</creatorcontrib><creatorcontrib>KWAK, UI JONG</creatorcontrib><creatorcontrib>RYU, GEUN HO</creatorcontrib><creatorcontrib>SHIN, HUI JAE</creatorcontrib><creatorcontrib>YOO, HEON SEUNG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HAN, CHANG GYUN</au><au>CHO, YONG BAEK</au><au>LEE, HAE IN</au><au>KWAK, UI JONG</au><au>RYU, GEUN HO</au><au>SHIN, HUI JAE</au><au>YOO, HEON SEUNG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Extraction and purification method of constituents from stem of Lonicera japonica Thunb. and the constituents of injection drug</title><date>2004-03-18</date><risdate>2004</risdate><abstract>PURPOSE: Provided is a method of extracting and purifying the effective active components from the aerial parts of Lonicera japonica which involves enhanced solubility and blood safety with excellent painkilling and anti-inflammatory effects. CONSTITUTION: The method of extracting and purifying the effective active components from the aerial parts of Lonicera japonica comprises the steps of: reflux-extracting the aerial parts of Lonicera japonica with water, and filtering it; adding the same amount of water-saturated short chain alcohol to isolate a layer; vacuum concentrating the alcohol layer to form a powder extract; purifying the extract with polyamide resin or polyvinylpyrrolidone resin; and purifying it with octadecylsilane. The short chain alcohol is butyl alcohol or propyl alcohol. The effective active components are sweroside and loganin.
본 발명은 인동등(인동잎을 제거한 인동줄기, 이하 인동등)으로부터 유효활성성분을 추출, 정제하는 방법 및 그 유효활성성분을 함유한 주사제 조성물에 관한 것으로서, 더욱 상세하게는 인동등으로부터 불필요한 탄닌과 난용성 플라보노이드, 사포닌 등의 성분을 제거하여 주사제 원료로 사용시 약효가 우수하며 그 유효성, 안전성 및 안정성이 뛰어난 스웨로사이드(sweroside), 로가닌(loganin)과 같은 이리도이드(iridoid)계 물질을 주성분으로 함유한 유효활성성분을 추출, 정제하는 방법 및 그 유효활성성분을 함유한 소염, 진통 주사제 조성물에 관한 것이다.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| title | Extraction and purification method of constituents from stem of Lonicera japonica Thunb. and the constituents of injection drug |
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