124- 124-Triazole derivatives processes for the preparation thereof and pharmaceutical compositions containing the same

PURPOSE: Provided are 1,2,4-Triazol derivatives which have improved fever alleviation, pain alleviation and inflammation inhibition activities, a method for preparing the same and a pharmaceutical composition containing the same. CONSTITUTION: 1,2,4-triazol derivatives represented by the formula(1) or nontoxic salts thereof are provided, wherein R1 is C3-C6 cycloalkyl, C3-C6 cycloalkenyl, phenyl, phenyl substituted by one or more substituent selected from C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halogen, amino, monoalkylamino, dialkylamino, nitro and cyano, styrenyl, C1-C6 alkoxy styrenyl, or pyridyl; R2 is methyl or amino; A, B, C and D are independently carbon or nitrogen. A method for preparing the 1,2,4-triazol derivatives of the formula(1) comprises reacting amidrazone derivatives of the formula(4a) with acylchloride of the formula(5) in the presence of base. 본 발명은 하기 화학식 1로 표시되는 디아릴 1,2,4-트리아졸 유도체 또는 그의 무독성 염, 이들의 제조방법, 및 이들을 유효성분으로 포함하는 약제학적 조성물에 관한 것이다. 본 발명에 따르면 해열, 진통, 소염작용을 가지며 부작용이 개선된 디아릴 1,2,4-트리아졸 유도체 또는 그의 무독성 염 및 이들의 제조방법 그리고 이들을 함유한 약제학적 조성물을 제공할 수 있다.