Novel phenylpyropene A and phenylpyropene B preparation method thereof and the pharmaceutical composition containing this
PURPOSE: Phenylpyropene A and phenylpyropene B, a preparation method thereof and a pharmaceutical composition containing the same are provided. The compounds inhibit cholesterol acyltransfer and cholesterol absorption, so that arteriosclerosis caused by hyperlipemia can be treated. CONSTITUTION: Phe...
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| Sprache: | eng ; kor |
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| Zusammenfassung: | PURPOSE: Phenylpyropene A and phenylpyropene B, a preparation method thereof and a pharmaceutical composition containing the same are provided. The compounds inhibit cholesterol acyltransfer and cholesterol absorption, so that arteriosclerosis caused by hyperlipemia can be treated. CONSTITUTION: Phenylpyropene A represented by the formula 1 is provided. Phenylpyropene B represented by the formula 2 is provided. A method for preparing the phenylpyropene A and phenylpyropene B comprises culturing Penicillium griseofulvum F1959(KCTC 0387BP), and isolating and purifying the phenylpyropene A and phenylpyropene B from the cultured medium. A pharmaceutical composition for the treatment of hyperlipemia contains the phenylpyropene A of the formula 1 and phenylpyropene B of the formula 2.
본 발명은 신규 화합물 페닐피로펜 A(phenylpyropene A)와 페닐피로펜 B(phenylpyropene B), 이의 생산방법 및 이를 포함하는 약제 조성물에 관한 것으로서, 더욱 상세하게는 페니실리움 그리세오플범() 균주로부터 얻은 아실-코에이:콜레스테롤 아실트란스퍼라제(ACAT, Acyl-CoA:cholesterol acyltransferase) 활성저해제인 신규 화합물 페닐피로펜 A와 페닐피로펜 B, 이들을 생산하는 방법 및 상기 페닐피로펜 A, 페닐피로펜 B 또는 이의 혼합물을 포함하는 고지혈증 치료용 약제 조성물에 관한 것이다. 본 발명에 따른 신규 화합물 페닐피로펜 A, 페닐피로펜 B 또는 이의 혼합물은 동맥경화 병변의 진전에 관여하는 콜레스테롤에 아실기 전이 대사를 저해하고 콜레스테롤 흡수를 저해함으로써 고지혈증으로 인한 동맥경화 및 순환기질환 치료에 매우 효과적으로 사용할 수 있다. |
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