Development of microsphere using carboxymethylcellulose

PURPOSE: Microsphere formulations obtained by coating microspheres of a drug and carboxy methyl cellulose with a non-aqueous material are provided. The formulations retain the activity of antigen material in the body and sustainingly release the antigen material to the body. CONSTITUTION: Formulations having a size of 0.1 to 200 microns are prepared by coating a non-aqueous material on the surface of microspheres of a drug and carboxy methyl cellulose or an inorganic salt thereof. The formulations use carboxy methyl amylose, gelatin, collagen, chitosan and alginate instead of the carboxy methyl cellulose. The non-aqueous material is selected from the group consisting of lipid such as lecithin, phosphatidylcholine, phosphatidyl ethanol amine, phosphatidyl inositol, a derivative thereof, fatty acid such as myristic acid, palmitic acid and stearic acid, etc. 본 발명은 카르복실 메틸 셀룰로오스에 백신 항원물질을 포함시킨 마이크로스피어의 표면을 비수성 물질로 코팅한 1~20um의 크기를 가지는 제형으로 체내에서 백신 항원물질의 활성을 유지하고 지속적으로 항원물질을 체내에 노출시켜 한번의 접종으로 충분한 역가를 나타내는 제제의 제조 방법에 관한 것이다.