Melanocortin receptor agonists

PURPOSE: A melanocortin 4 receptor(MC4R) agonist is provided, thereby accelerating the function of the melanocortin 4 receiptor(MC4R), and consequently preventing and treating diseases associated with the MC4R such as obesity, penile erection disorder, diabetes and inflammation. CONSTITUTION: Compounds functioning as a melanocortin 4 receptor(MC4R) agonist are represented by formula(1), wherein A is hydrogen, COR1, CO2R1, SO2R1, SO2NHR1, SO2N(R1)2, PO(OR1)2, C1-C8-alkyl, (CH2)n-C5-C10-aryl or (CH2)n-C5-C10-heteroaryl in which R1 is hydrogen, C1-C8-alkyl, (CH2)n-C3-C7-cycloalkyl, (CH2)n-C5-C10-aryl or (CH2)n-C5-C10-heteroaryl, n is an integer of 0 to 7; B and C are independently hydrogen, C1-C8-alkyl, (CH2)n-C3-C7-cycloalkyl, (CH2)n-C5-C10-aryl, (CH2)n-C5-C10-heteroaryl, (CH2)n-C5-C10-heterocycle or (CH2)n-O(CH2)-C5-C10-aryl in which n is an integer of 1 to 7; D is hydrogen, C1-C8-alkyl, (CH2)n-C3-C7-cycloalkyl, (CH2)n-C5-C10-aryl, (CH2)n-C5-C10-heteroaryl, (CH2)n-C5-C10-heterocycle or (CH2)n-O(CH2)-C5-C10-aryl in which n is an integer of 1 to 7; E is C5-C10-alkyl or (CH2)m-C5-C7-cycloalkyl in which m is an integer of 0 to 2; and F is (CH2)m-C5-C10-heteroaryl or (CH2)m-C5-C10-heterocycle in which n is an integer of 0 to 2. 본 발명은 멜라노코틴 수용체에 대한 항진활성이 우수한 하기 화학식 1의 화합물, 약제학적으로 허용되는 그의 염, 수화물, 용매화물 및 이성체, 및 이를 유효성분으로 함유함을 특징으로 하는 멜라노코틴 수용체의 기능항진제 조성물에 관한 것이다: 상기식에서 A, B, C, D, E 및 F는 명세서에 정의한 바와 같다.