Melanocortin receptor agonists

PURPOSE: Provided is a composition of melanocortin receptor(MRC) agonists, containing, as an active ingredient, a compound of formula(1), its pharmaceutically acceptable salt, a hydrate, a solvate and an isomer. CONSTITUTION: The composition of melanocortin receptor(MRC) agonists comprises a compound of the formula(1) having excellent antagonistic action on melanocortin receptor. In the formula(1), Y is as defined in the specification; X is H2, O or S; B is hydrogen, substituted or unsubstituted C1-C8 alkyl, (CH2)n-C3-C8 cyclo alkyl, (CH2)n-C3-C10 aryl, (CH2)n-C3-C10-hetero aryl, (CH2)n-C3-C10-hetero cyclo alkyl or (CH2)n-O(CH2)-C3-C10-aryl, wherein n is an integer of from 1 to 7; C is substituted or unsubstituted C1-C8 alkyl, (CH2)m-C3-C8 cyclo alkyl, (CH2)m-C3-C10 aryl, (CH2)m-C3-C10-hetero aryl, (CH2)m-C3-C10-hetero cyclo alkyl, wherein m is an integer of from 0 to 2; and D is (CH2)m-R2, wherein m is an integer of from 0 to 3. 본 발명은 멜라노코틴 수용체에 대한 항진활성이 우수한 하기 화학식 1의 화합물, 약제학적으로 허용되는 그의 염, 수화물, 용매화물 및 이성체, 및 이를 유효성분으로 함유함을 특징으로 하는 멜라노코틴 수용체의 기능항진제 조성물에 관한 것이다: [화학식 1] 상기 식에서 Y, B, C, D, X 는 명세서에 정의한 바와 같다.