Novel antiviral peptide derived from Helicobacter pylori and use thereof
PURPOSE: An antiviral peptide derived from Helicobacter pylori and the use thereof are provided,. The antiviral peptide has no cell toxicity but improved virus-cell fusion-inhibiting activity, so that it can be useful as a safe human antiviral agent. CONSTITUTION: The antiviral peptide derived from...
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Zusammenfassung: | PURPOSE: An antiviral peptide derived from Helicobacter pylori and the use thereof are provided,. The antiviral peptide has no cell toxicity but improved virus-cell fusion-inhibiting activity, so that it can be useful as a safe human antiviral agent. CONSTITUTION: The antiviral peptide derived from Helicobacter pylori having virus-cell fusion-inhibiting activity has the amino acid sequence of SEQ ID NO: 2, wherein the antiviral peptide is prepared by substitution of amino acids in the amino-terminal region of ribosomal protein L1(RPL1) derived from Helicobacter pylori; the amino-terminal region of the RPL1 is a peptide HP(2-20) having the amino acid sequence of SEQ ID NO: 1; the amino acids 17, glutamine, and amino acids 19, asparaginic acid, in the peptide HP(2-20) of SEQ ID NO: 1 are substituted by other hydrophobic amino acids except for tryptophan; the hydrophobic amino acid is selected from the group consisting of alanine, isoleucine, methionine, phenylalanine, proline, valine and leucine; one or more amino acids selected from the amino acids 8, arginine, amino acids 10, glutamic acid, and amino acids 20, lysine, in the peptide HP(2-20) of SEQ ID NO: 1 are substituted by amino acids selected from the group consisting of tryptophan, alanine, isoleucine, methionine, phenylalanine, proline, valine and leucine.
본 발명은 헬리코박터 파일로리() 균이 생산하는 리보좀 단백질 L1(ribosomal protein L1, RPL1)의 아미노말단(amino-terminal) 부위를 다른 아미노산으로 치환시켜 합성한 항바이러스 펩타이드 및 그의 용도에 관한 것으로서, 구체적으로 RPL1 단백질의 아미노말단 부위 중 양친화성(amphipathic)을 갖고 있는 펩타이드인 HP (2-20)의 친수성 부위를 소수성 아미노산으로 치환시켜 소수성 영역을 증가시키는 양친화성 구조로 합성한로 기재되는 항바이러스 펩타이드 및 그의 용도에 관한 것이다. 본 발명의 항바이러스 펩타이드 및 그의 유도체는 세포독성이 없고 탁월한 바이러스-세포 융합저해 활성을 나타내므로 인체에 안전한 항바이러스제로 유용하게 사용될 수 있다. |
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