Method of preparing levosulpiride and intermediates used therein

Method of preparing levosulpiride and intermediates used therein

PURPOSE: Provided are a method for preparing Levosulpiride which increases the pressure of a sphincteral muscle, promotes the vermiculation of the gullet and facilitates digestion, in high yield and purity and intermediates used therein. CONSTITUTION: The method for preparing Levosulpiride of the fo...

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Bibliographische Detailangaben
Hauptverfasser: WOO, HYE GYEONG, KIM, JONG HO, PARK, TAE HO, YOON, JIN YEONG, WANG, HAN CHEOL, YANG, MIN SEUNG
Format: Patent
Sprache:eng ; kor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:PURPOSE: Provided are a method for preparing Levosulpiride which increases the pressure of a sphincteral muscle, promotes the vermiculation of the gullet and facilitates digestion, in high yield and purity and intermediates used therein. CONSTITUTION: The method for preparing Levosulpiride of the formula(I) is characterized by treating a compound of the formula(V) with trifluoroacetate. In the formulae, R1 and R2 are independently hydrogen atom or 1-4 of lower alkyl or phenyl; R3 is a phenyl derivative of the formula(VIII) or naphthyl derivative of the formula(IX). 본 발명의 방법에 의하여 식도의 괄약근압력을 증가시키고 식도연동운동을 촉진하며, 위장의 음식분쇄, 배출 등 소화작용을 촉진하며, 음식물의 소화관 이동시간을 빠르게 하는 약제인 다음 구조식 (I)의 레보설피리드((S)-N-[(1-에틸-2-피롤리딘일)메틸]-2-메톡시-5-설파모일벤즈아미드)를 고순도 및 고수률로 제조할 수 있다.