Antibacterial agent for oral pathogens

PURPOSE: An antimicrobial agent separated from Mori Cortex Radicis showing strong antimicrobial activity against Streptococcus mutans and Porphyromonas gingivalis as a causative agent of tooth decay and periodontal disease is provided which can exhibit a very fast antimicrobial effect within a very...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KIM, JI EUN, YOO, JAE SEON, HWANG, JAE GWAN, SIM, JAE SEOK, PARK, GYEONG MIN
Format: Patent
Sprache:eng ; kor
Schlagworte:
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Beschreibung
Zusammenfassung:PURPOSE: An antimicrobial agent separated from Mori Cortex Radicis showing strong antimicrobial activity against Streptococcus mutans and Porphyromonas gingivalis as a causative agent of tooth decay and periodontal disease is provided which can exhibit a very fast antimicrobial effect within a very short time of about 3min for tooth brushing. CONSTITUTION: The antimicrobial agent against harmful microorganisms contains Kuwanon G of the formula 1 separated from Mori Cortex Radicis. For example, 100g Mori Cortex Radicis is extracted with 400ml methanol and filtered with No.2 Whatman filter paper, and the extract is concentrated in a vacuum rotary concentrator to remove the solvent and then freeze dried to remove water. 본 발명은 상백피로부터 분리된 구와논 지(kuwanon G)의 충치 유발균인 스트렙토코커스 뮤턴스()와 치주질환 유발균인 포피로모나스 진지바리스()대한 항균활성에 관한 것으로 본 발명의 항균활성 물질은 저분자 물질로서 고온에서도 안정하고 종래의 대부분의 항균활성 물질에 비하여 유해 구강미생물에 대한 항균활성이 높을 뿐만 아니라 천연물로부터 분리한 성분이어서 부작용 없이 우수한 항균활성을 나타낸다.